PRF, Platelet Rich Fibrin
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PRF (Platelet Rich Fibrin) represents a new approach in the field of orthopaedic medicine, particularly in cartilage repair. At the London Cartilage Clinic, we specialise in PRF therapy to address knee cartilage injuries. This technique involves using a patient's own blood to create a concentrated source of platelets and growth factors, aiding in the natural healing process.
Reviewed byProf Paul Lee MBBch, FRCS (Tr & Orth), PhDLast reviewed 1 May 2026
Understanding PRF therapy
for cartilage support
PRF (platelet-rich fibrin) is an autologous blood-derived matrix that delivers platelets and growth factors in a sustained-release form.
Compared with standard PRP preparations, PRF provides a fibrin scaffold that may support a longer biological effect at the treatment site.
- Autologous material with low immunological concern.
- Applied in cartilage and soft-tissue regenerative pathways.
- Often used as part of a broader personalised treatment plan.
PRF applications at London Cartilage Clinic
from knee cartilage to meniscus
PRF is used at our clinic to improve the biological environment in tissues with limited self-healing capacity, especially in the knee.
- Cartilage-focused pathways for selected chondral injuries.
- Adjunctive use in meniscus repair to support healing response.
- Integrated planning with imaging, symptom profile, and activity goals.
We use PRF where it is clinically appropriate, with transparent expectations around recovery, symptom response, and potential need for combined therapies.
You may have more options than you think
Most patients have more treatment options than they have been told
At London Cartilage Clinic we follow a structured clinical framework across four areas of treatment. Before recommending a single procedure, we assess which combination of approaches gives you the best outcome.
Preserve
Protect what you have. Slow degeneration and manage symptoms.
Repair
Fix specific damage. Torn tissue, unstable joints, structural problems.
Regenerate
Rebuild lost tissue. Biological treatments that stimulate new growth.
Replace
When other options are exhausted. Joint replacement as a last resort.
This treatment can be applied across multiple joints. Select yours to see the full range of options we offer, organised by clinical approach.
Explore All Treatment Options
Frequently Asked Questions
What is Platelet Rich Fibrin (PRF)?
PRF is a second-generation platelet concentrate, richer and more effective than its predecessor, PRP. It is created from the patient’s own blood and is used to accelerate the healing of injured tissues, including cartilage.
How is PRF applied in cartilage repair?
In PRF therapy, a concentration of platelets and growth factors is applied directly to the injured cartilage site. This method promotes natural healing and regeneration of the cartilage tissue, particularly in the knee.
Who is an ideal candidate for PRF therapy?
PRF therapy is suitable for individuals suffering from cartilage injuries, particularly in the knee. It is especially beneficial for patients looking for a natural and minimally invasive treatment option.
What are the benefits of PRF over traditional methods?
PRF offers a natural, autologous approach to healing, reducing the risk of rejection and complications. Its slow release of growth factors provides a sustained healing environment, enhancing the overall efficacy of cartilage repair.
Still have more specific concerns?
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